Archive for March, 2022

Longevity is desperately searched for by people of old age. Read the tips below to live longer.

Are there any supplements not suggested by David Sinclair?

Not all supplements serve the purpose of anti-aging. In fact, many supplements are harmful and can easily fasten the aging symptoms. Apart from Metformin, NMN, Alpha Lipoic Acid, Resveratrol, Vitamin K2 and D3, Statin,  and Coenzyme Q10, some pills are not recommended by Sinclair. The following supplements fall in this list and should be avoided at all costs, as revealed by David Sinclair.


1.   Branched chain amino acids (BCAAs)

This compound activates mTOR, and by doing so, muscle production is boosted. However, the lifespan is reduced as well.

2.   NAD+

This is a naturally occurring big-sized molecule that is unable to penetrate or get absorbed easily as it is large. Therefore, David Sinclair proposes to take NMN instead as an alternative.

3.   Rapamycin

Rapamycin obstructs mTOR and slows down the aging process. But due to the lack of safety evidence, this supplement is risky.

The Hacks Of Longevity By David Sinclair

Other Tips For Longevity

  • If you are overweight or obese, take the necessary steps to lose weight.
  • Do not compromise on sleep and rest.
  • Decrease your protein consumption, particularly red meat.
  • Eat all types of vegetables.
  • Do not overeat.
  • Do intermittent fasting sometimes. David skips some meals in a day.
  • Reduce your exposure to UV rays and X-rays.

Eat Healthily

David Sinclair does not share much about his dietary specifications. But he does share some important points that need to be remembered regarding food regimen:


  • Eat less meat and incorporate more plants into your diet. Eating more plant-based foods elongates the lifespan.
  • Decrease sugar intake because science has revealed that high glucose levels increase the aging clock.


Doing exercise provides great advantages like increasing the NAD+ levels in the body. All the molecules and longevity regulators such as AMPK, mTOR, and Sirtuins genes are all activated with continuous exercise. In his book, David Sinclair suggests that:


  • Focus on high intensity instead of low intensity.
  • The end results of your exercise should make you sweat and unable to speak except some words without breathing. This is called a hypoxic response.
  • The breathing should be quick and deep at 70 to 80% of a high heartbeat.
  • You should aim to boost your heart rate and breathing rate.

Cold Temperature

When you are exposed to unpleasant temperatures, the longevity genes get activated. This speeds up the brown fat also known as brown adipose tissue. The main factor is to exert a tolerable amount of stress, and this is exactly what exposure to cold temperature does.

However, the temperature should not be enough to cause a fever. In his book, David Sinclair mentions the following methods to induce cold temperature:

  • Do exercise in the cold season.
  • Open any window throughout the day.
  • Take a cold shower.
  • Do not turn on the heater in the winter.
  • Don’t sleep with a heavy blanket.
  • In winter, wear fewer layers of clothes.


Heat therapy is also a method for increasing the lifetime, and it can offer the same benefits. But David Sinclair prefers the cold method as it is supported by more evidence and scientific research.